Coordination of host pathogen protein-protein interactions during flavivirus and coronavirus infections
Viruses have evolved sophisticated strategies to co-opt host cellular processes to facilitate viral replication. Host-pathogen protein-protein interactions govern all processes of the viral life cycle including viral entry, disassembly, replication, assembly and suppression of the cellular immune response. In particular, hijacking of cytosolic and ER proteostasis pathways has emerged as a common strategy for viral replication that might extend beyond simply facilitating the folding of viral proteins. Our research elucidates the timing and coordination of host pathogen protein interactions throughout the viral life cycle with a particular focus on uncovering novel dependencies on the host proteostasis pathways. Our discoveries point to new host processes as therapeutic targets to combat infection of several widespread viruses that pose global health threats, such as Dengue, Hepatitis C, or Zika Virus.